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Danish firm wins US contract for new smallpox vaccine

first_img Jun 4 HHS news release HHS said phase 1 studies supported by the National Institutes of Health in 2003 showed that MVA vaccine was safe and stimulated an immune response in healthy volunteers. The agency also has said an MVA-based vaccine was found to be safe when it was given to 120,000 Germans in the 1970s. But research on MVA ended when smallpox was declared eradicated in 1980. Options in the contract, amounting to $1.1 billion, include delivery of up to 60 million more doses of the vaccine, plus further clinical studies to extend the FDA license to include people infected with HIV, children, and the elderly, the company said. Bavarian Nordic, based in Copenhagen, will produce its “next generation” smallpox vaccine, called Imvamune, for the Department of Health and Human Services (HHS), HHS Secretary Mike Leavitt announced in a news release yesterday. Imvamune is the company’s version of modified vaccinia Ankara (MVA). “Acquiring a stockpile of this new smallpox vaccine is a key step toward protecting even more members of the American public against a smallpox release,” Leavitt commented. Jun 5, 2007 (CIDRAP News) – US officials have announced the award of a $500 million contract to Bavarian Nordic A/S, a Danish firm, for 20 million doses of a smallpox vaccine that’s expected to be safe for people with weakened immune systems. Jun 4 Bavarian Nordic news release Under the original BioShield legislation, HHS can make an advance payment on the basis of a finding that it is necessary to the success of the product. Under the Pandemic and All-Hazards Preparedness Act of 2006, the company can be paid for reaching certain milestones in development, HHS reported. Dr. Paul Chaplain, Bavarian Nordic’s executive vice president and chief scientific officer, noted that HHS has a policy permitting the emergency use of medical products not yet licensed by the FDA, provided they meet certain criteria. To meet those criteria, the company must generate safety data from trials of the vaccine in healthy people and at-risk groups such as HIV patients, demonstrate a validated manufacturing process, and have some efficacy data, he told CIDRAP News. The contract includes options that may bring its total value to $1.6 billion, according to Bavarian Nordic. Besides covering production of the vaccine, the base contract of $500 million covers additional work to meet requirements for use of the vaccine in an emergency, plus nonclinical and clinical studies necessary to obtain a Food and Drug Administration license (FDA) for it, the company said. HHS has stockpiled enough conventional smallpox vaccine to protect the entire US population in the event of a release of smallpox by terrorists. But the conventional vaccine uses live vaccinia virus, a cousin of the smallpox virus, and it can cause rare but potentially life-threatening side effects. People who have HIV or are being treated with chemotherapy should not receive the conventional vaccine except in emergencies, HHS said. In a news release, Bavarian Nordic said advance and milestone payments in the contract total $150 million, of which $125 million is to be paid in 2007 and 2008. The company said this is the first time any company will have received advance payments under the BioShield program. Chaplain said the company is capable of making 40 million doses of the vaccine annually and could potentially start delivering doses to HHS immediately. But because the firm first must provide all the data to support emergency use of the vaccine, it expects to start delivering it toward the end of next year, he said. Bavarian Nordic announced in April that it expected to win the HHS contract, but HHS said then that no decision had been made yet. Bavarian Nordic and the British drug company Acambis each received an HHS contract in early 2003 to develop and test a vaccine based on MVA. In September 2004 HHS awarded each company a further contract calling for production of 500,000 doses of the vaccine and clinical trials. But Acambis announced in November 2006 that HHS had decided that the company’s vaccine was too expensive. “And in fact we have most of that data already,” Chaplain said. The company has tested the vaccine in about 1,500 people, including healthy people and at-risk groups, and has published data on the vaccine’s efficacy in monkeys and other animals, he said. Although smallpox was eradicated, disease experts fear that terrorists may have supplies of the virus, which the Soviet Union made in large quantities during the Cold War. The United States and Russia still hold samples of the smallpox virus for research purposes. MVA contains a form of vaccinia virus that has been weakened so that it can’t replicate in humans, the agency said. Officials expect that it could be used safely in the estimated 10 million Americans who have limited immunity. The vaccine is being tested with a two-dose immunization schedule. See also: HHS said the contract was awarded under Project BioShield, a federal program launched in 2004 to develop medical countermeasures for chemical, biological, and other unconventional weapons. The contract allows for the agency to make two kinds of payments before delivery of the product. Chaplain also said the company expects to start filing its application for an FDA license in 2009 and complete the filing process in 2010. Phase 2 studies are approaching completion, and plans call for meeting with the FDA later this year to discuss phase 3 studies, with an expectation to launch them next year, he added. Apr 18 CIDRAP News story “Danish firm expects to sell smallpox vaccine to US” read more

Ante Ančić became the director of sports development of the BTravel agency

first_imgUntil recently, the director of the European Handball Championship for the City of Zagreb, Ante Ančić, became a new member of the BTravel agency, one of the fastest growing Croatian and regional tourist agencies.Ante Ančić in BTravel is engaged in the position of director for sports development and one of the main projects he will develop is the placement of Croatia on foreign markets as an ideal destination for sports preparations, but also for sporting events. Ante Ančić will also be responsible for taking over some new acquisitions of BTravel in Croatia.”Ante Ančić’s invaluable sports experience and contacts with people from various sports segments will greatly contribute to the development of our business processes. In addition to sports, we see this acquisition as a powerful way to enter certain emitting markets where people are very attached to their sports clubs, whether they are active athletes or support sports in various other ways.. “, pointed out Dalibor Bilić, President of the Management Board of BTravela.Ante Ančić started his professional career in sports circles in 2012 as the technical secretary of the Zagreb Handball Club, and since 2013 he has taken the position of club director. He is also known to the public for his position as the director of the competition during the World Handball Championship in Zagreb in 2009, but also as the director of the European Handball Championship for the City of Zagreb.In addition to business and incoming tourism, and the MICE segment, an important part of BTtavel’s business is sports tourism, ie co-organization of events and service for clubs and associations. In this business segment, BTravel plans to grow by 100% this year compared to the previous year. The basis of sports tourism that BTravel works and develops is the presentation of Croatia in the world as a destination that has all the necessary sports infrastructure for the organization of sports preparations, camps, events, etc. for foreign clubs and associations. In the past two years, we can boast of organizing several major sporting events with more than 1000 participants, point out BTravel.Related news: DALIBOR BILIĆ, BTRAVEL: WE SEE FURTHER DEVELOPMENT IN THE DEVELOPMENT OF DIGITAL PLATFORMS THAT WILL CONNECT SOCIAL NETWORKS, TOURISM AND WELLBEINGlast_img read more

Wildcats Sweep Spartans In Weekend DH

first_imgFranklin County defeated Connersville in Game 1 of a doubleheader Saturday, 6-0. Joe Monroe pitched a complete game shutout, needing just 72 pitches and struck out 7 Spartans. The Wildcats were led by Brennan Meyers with 3 hits and 3 RBI’s. Logan Winters also contributed with 2 RBI’s.In the second game of the conference doubleheader with Connersville, FC, the visiting team on the scoreboard, came out on top 7-1 to end the regular season. Alex Bischoff started the game for FC, but with sectional approaching, came out after 2 innings of shutout pitching due to pitch count limit. Grant Smith pitched the final 5 innings to get the win, allowing just 1 run that came in the bottom of the 7th inning.Offensively, Logan Winters, Grant Smith, and Trevin Manderschied all had 2 hits games. Blake Ripperger, Winters and Smith each knocked in 2 runs.Franklin County finished the season with an overall record of 17-5. In EIAC play, FC finished 10-4 for 3rd place behind Lawrenceburg (13-1) and Batesville (13-3).The Wildcats will begin Sectional play at South Dearborn on Wednesday when they will take on the Rushville Lions. First pitch is scheduled for 5:30.last_img read more

Kamrup storms into final of the All Assam Veteran Inter District and Inter Institution Cricket tournament

first_imgOur Sports ReporterGUWAHATI: Kamrup stormed into the final of the All Assam Veteran Inter District and Inter Institution Cricket tournament as they beat Guwahati by 45 runs in the first semifinal at Mangaldoi today.After winning the toss, Kamrup scored 171 runs in allottoed 20 overs losing 7 wickets. Continuing his good form Mukut Kalita played another match winning knock of 67 in 40 balls with 9 fours and 3 sixes. In reply Guwahati veterans ould manage 126 in 20 overs losing 9 wickets.Brief Score: Kamrup 171/7 in 20 overs (Mukut Kalita 67, Nitin Das 3/30) beat Guwahati 126/9 in 20 overs (Nausad Ali 35, Debajit Basumatari 3/24, Bhaskarjyoti Barman 3/15). Also read: Local Sportslast_img read more

Vogel paces Trojans at home event

first_imgUSC freshman T.J. Vogel fired a second-round 63, a tournament low and two strokes off the course record, on his way to a second place finish Tuesday at the USC Collegiate Invitational at the North Ranch Country Club in Westlake Village, Calif.Vogel’s strong play led the No. 16 Trojans to a tie for fourth in their home event, finishing 20 strokes behind tournament champions No. 17 Oregon.After an up-and-down first round Monday morning, Vogel lit up the course in the afternoon, shooting the best score of his young collegiate career.“In order to win a national title, we need guys that can flat out play,” USC coach Chris Zambri said. “And when somebody shows that they can, that’s huge.”Vogel got off to a quick start, making birdies on four of his first six holes. After playing the next six holes to even par, Vogel hit his tee shot into the water on a par 3 and made a double bogey on his 13th hole of the day.He bounced back immediately, making eagle on the next hole, a 522-yard par 5. Vogel closed his round with four consecutive birdies to post an 8-under-par 63.Vogel began Tuesday’s final round with the lead but Oregon’s Eugene Wong shot 69 to Vogel’s 71 to take the title by one shot. Vogel missed a 20-foot putt on his last hole for birdie that would have tied him with Wong.“We felt at the beginning of the year that he was a real key to our success,” Zambri said about Vogel. “To have him get it going is great.”Sophomore Steve Lim also turned in a solid performance for the Trojans, shooting 69-73-69 to finish in a tie for 13th at 2 under par.Freshman Martin Trainer overcame an opening round 77 to finish 73-70 and tie for 48th. Redshirt junior Bo DeHuff shot 75-74-75 to finish in a tie for 60th.The struggles continued for USC’s two-time All-American Matt Giles, who shot 69-77-83 to finish in a tie for 75th in the 80-man field.“My ball striking this week was absolutely terrible,” Giles said. “It was flat out embarrassing.”Zambri said he thought the tough outing would actually benefit Giles.“Sometimes that stuff happens, and it really forces you to evaluate what you’re doing,” Zambri said. “I think it’s something that’s going to end up being very helpful for Matthew to have gone through this week the way he did.”Three Trojans played in the tournament as individuals. Freshman Stewart Hagestad finished tied for 43rd, junior Daniel Park tied for 53rd and freshman Sam Smith tied for 73rd.USC finished the tournament in the middle of the Pac-10 teams competing, finishing behind Oregon (first), No. 21 California (second) and No. 14 Arizona State (third) and in front of No. 2 Stanford (eighth), No. 11 UCLA (ninth) and No. 15 Oregon State (tied for 12th).“We’re going to have to get better and play better if we’re going to compete with teams like [Oregon],” Zambri said.The Trojans will return to action next Friday, March 12, at the Southern Highlands Collegiate in Las Vegas.last_img read more

Greg Olsen injury update: Panthers TE (foot) placed on IR

first_imgOlsen ruptured his right plantar fascia during Sunday’s loss to the Buccaneers. The 33-year-old caught 27 passes for 291 yards and four touchdowns this season. Related News Greg Olsen is done for the year.The Panthers on Wednesday announced the veteran tight end has been placed on injured reserve, ending his season. This will be the second straight year in which he has been placed on the IR. He was also put on the IR last season when he suffered a fracture in his right foot.Carolina is 6-6 on the season and in seventh place in the NFC playoff race entering its Week 14 matchup at Cleveland. Greg Olsen injury update: Panthers TE (foot) expected to miss rest of seasonlast_img read more

Kawhi Leonard free agency rumors: Teams warned not to leak meeting info

first_img“I was told to not to expect a decision until at least later (Wednesday), possibly (Thursday) on July 4th.”So far everything about Leonard’s free agency has been kept under wraps. The Lakers reportedly are optimistic because of the recruiting efforts by LeBron James and Magic Johnson. Leonard also was seen Wednesday after touching down in Toronto, although there is no indication why he is in the city.The MLSE plane has landed in Toronto and someone is here 👀👀.(Via: @CP24)— TSN (@TSN_Sports) July 3, 2019Leonard, 28, averaged 30.5 points in the playoffs, was named the Finals MVP and helped the Raptors avoid elimination by knocking down a crazy bouncing buzzer-beater in the fourth quarter of Game 7 against the 76ers in the second round. Related News While many NBA stars had intense media scrutiny with reports emerging hourly of their every move, Leonard is taking a different approach, according to ESPN’s Adrian Wojnarowski.”Teams have simply been told this, ‘If information on your presentation gets out, you’re really imperiling your chance to sign Kawhi Leonard.’ And so you understand why teams are keeping this so private. And his camp has not allowed that information to really get out,” Wojnarowski said on “Get Up!” Wednesday morning. NBA trade rumors: Grizzlies unload Chandler Parsons, $25M contract with Hawks Kawhi Leonard’s camp has a strong message for the NBA teams he’s meeting with as a free agent: Don’t leak anything that goes on in those meetings.Leonard, who is an unrestricted free agent, has teams clamoring for him, especially after his performance in leading the Raptors to their first title. Celtics hire former WNBA star Kara Lawson as assistant NBA free agency rumors: Boban Marjanovic signs with Maverickslast_img read more

James Wiseman deemed ineligible by NCAA, plays for Memphis anyway after judge blocks ruling

first_imgDeCOURCY: Memphis fans who remember ‘strict liability’ view NCAA with suspicionLeslie Ballin, one of Wiseman’s attorneys, told reporters at a news conference (per the Memphis Commercial Appeal) that the judge in Shelby County, Tenn. (Memphis is the county seat), placed a hold on the NCAA’s ruling, pending “further litigation.” A Memphis spokesman said in a prepared statement that the university “is currently working with the NCAA staff to restore his playing status, and we are hopeful for a speedy resolution to the matter.”NBA MOCK DRAFT 2020: James Wiseman a top-five pick in SN’s latest”We didn’t know that it was going to go that way,” Memphis coach Penny Hardaway told ESPNU after the game. Wiseman finished with 17 points and nine rebounds in the Tigers’ 92-46 victory.The NCAA released a statement later Friday that held Memphis responsible for allowing Wiseman to play.NCAA statement on James Wiseman:— Inside the NCAA (@InsidetheNCAA) November 9, 2019Hardaway declined to comment to ESPNU about the statement, although he said earlier in the interview that the decision to allow Wiseman to play after the ruling was “up to the school.””Obviously, James has a right to do what he did,” Hardaway told ESPNU of Wiseman suiting up.Earlier, Ballin told reporters (per ESPN’s Adrian Wojnarowski) that the NCAA’s ruling involved Memphis coach Penny Hardaway, who helped Wiseman’s family move from Nashville to Memphis in 2017 while Hardaway was coaching in high school in the city. Wiseman played for Hardaway at Memphis’ East High School in 2017-18, and then followed Hardaway to Memphis months after the Tigers legend took over the program in 2018.Memphis said in its statement that Hardaway provided $11,500 in “moving expenses” to Wiseman’s family without Wiseman’s knowledge. Memphis freshman big man James Wiseman played in the Tigers’ game vs. Illinois-Chicago on Friday despite being ruled ineligible by the NCAA.The university said (per college basketball reporter Andy Katz) that a temporary restraining order issued by a Tennessee judge allowed Wiseman to stay on the court for the time being. Hardaway had kept Wiseman off the court for Memphis’ preseason exhibition in October; the coach told media that Wiseman was dealing with an ankle injury. Wiseman did not play during the Tigers’ preseason trip to the Bahamas, either, because of a shoulder injury. Friday’s announcement added the possibility that Hardaway was also holding out Wiseman over eligiblity concerns, even though Wiseman played in Memphis’ season opener Nov. 5 vs. South Carolina State.The 7-1 Wiseman is considered a high lottery pick in the 2020 NBA Draft. He was the No. 1-ranked player in 247Sports’ Class of 2019 when he committed to Memphis in November 2018.This article has been updated with Wiseman playing on Friday, the NCAA’s statement, the fact Wiseman’s family moved from Nashville, and the fact Wiseman had already played for Memphis.last_img read more

What channel is Eagles vs. Giants on today? Schedule, time for Week 17 NFL game

first_imgPhiladelphia heads into Sunday’s game having won three straight while New York’s won two straight.NFL schedule Week 17You can keep up with live scores and stats with SN’s live scoreboard.Note: National broadcasts are listed in bold.Sunday, Dec. 29GameTimeChannelJets vs. Bills1 p.m. ETCBS, fuboTVBrowns vs. Bengals1 p.m. ETFox, fuboTVPackers vs. Lions1 p.m. ETFox, fuboTVChargers vs. Chiefs1 p.m. ETCBS, fuboTVBears vs. Vikings1 p.m. ETFox, fuboTVDolphins vs. Patriots1 p.m. ETCBS, fuboTVFalcons vs. Buccaneers1 p.m. ETFox, fuboTVSaints vs. Panthers1 p.m. ETFox, fuboTVRedskins vs. Cowboys4:25 p.m. ETFox, fuboTVRaiders vs. Broncos4:25 p.m. ETCBS, fuboTVCardinals vs. Rams4:25 p.m. ETFox, fuboTVEagles vs. Giants4:25 p.m. ETFox, fuboTVColts vs. Jaguars4:25 p.m. ETCBS, fuboTVSteelers vs. Ravens4:25 p.m. ETCBS, fuboTVTitans vs. Texans4:25 p.m. ETCBS, fuboTV49ers vs. Seahawks8:20 p.m. ETNBC, fuboTVEagles schedule 2019WeekDateOpponentKickoff timeTVWeek 1Sept. 8vs. Redskins (W, 32-37)1 p.m. ETFOXWeel 2Sept. 15at Falcons (L, 24-20)8:20 p.m. ETNBCWeek 3Sept. 22vs. Lions (L, 27-24)1 p.m. ETFOXWeek 4Sept. 26 (Thursday)at Packers (W, 34-27)8:20 p.m. ETFOXWeek 5Oct. 6vs. Jets (W, 31-6)1 p.m. ETCBSWeek 6Oct. 13at Vikings (L, 38-20)1 p.m. ETFOXWeek 7Oct. 20at Cowboys (L, 37-10)8:20 p.m. ETNBCWeek 8Oct. 27at Bills (W, 31-13)1 p.m. ETFOXWeek 9Nov. 3vs. Bears (W, 22-14)1 p.m. ETFOXWeek 10BYEWeek 11Nov. 17vs. Patriots (L, 17-10)4:25 p.m. ETCBSWeek 12Nov. 24vs. Seahawks (L, 17-9)8:20 p.m. ETNBCWeek 13Dec. 1at Dolphins (L, 37-31)1 p.m. ETFOXWeek 14Dec. 9 (Monday)vs. Giants (W, 23-17)8:15 p.m. ETESPNWeek 15Dec. 15at Redskins (w, 37-27)1 p.m. ETFOXWeek 16Dec. 22vs. Cowboys4:25 p.m. ETFOXWeek 17Dec. 29at Giants1 p.m. ETFOXGiants schedule 2019WeekDateOpponentKickoff timeTVWeek 1Sept. 8at Cowboys4:25 p.m. ETFOXWeel 2Sept. 15vs. Bills1 p.m. ETCBSWeek 3Sept. 22at Buccaneers4:05 p.m. ETFOXWeek 4Sept. 29vs. Redskins1 p.m. ETFOXWeek 5Oct. 6vs. Vikings1 p.m. ETFOXWeek 6Oct. 10 (Thursday)at Patriots8:20 p.m. ETFOXWeek 7Oct. 20vs. Cardinals1 p.m. ETFOXWeek 8Oct. 27at Lions1 p.m. ETFOXWeek 9Nov. 4 (Monday)vs. Cowboys8:15 p.m. ETESPNWeek 10Nov. 10at Jets1 p.m. ETFOXWeek 11BYEWeek 12Nov. 24at Bears1 p.m. ETFOXWeek 13Dec. 1vs. Packers1 p.m. ETFOXWeek 14Dec. 9 (Monday)at Eagles8:15 p.m. ETESPNWeek 15Dec. 15vs. Dolphins1 p.m. ETCBSWeek 16Dec. 22at Redskins1 p.m. ETFOXWeek 17Dec. 29vs. Eagles1 p.m. ETFOX The Eagles look to clinch the NFC East as they travel north to take on the Giants in Week 17 on Sunday.Philadelphia (8-7) is coming off a crucial victory over the Cowboys in Week 16 that vaulted them into first place in the division. A win on Sunday would punch the Eagles’ ticket to the postseason and send the Cowboys packing. Despite their depleted receiving corps., the Eagles have come on strong as of late winning their last three games.  MORE: Watch Eagles vs. Giants live with fuboTV (7-day free trial)New York (4-11) hasn’t had much to revel in this season. The team’s win over Washington last week took it out of contention for the No. 2 pick in the 2020 NFL Draft, ensuring one of their division rivals a top talent for years to come. However, the Giants would love to spoil the Eagles’ playoff hopes and ending their season on a strong note bodes well for the 2020 season.With a win on Sunday, the Eagles would host the Vikings in the NFC wild-card round next weekend.Here’s everything you need to know to watch the Eagles vs. Giants game on Sunday, including kickoff time, TV channels and a full Week 17 NFL schedule.MORE: How the Eagles can clinch NFC’s last playoff spotWhat channel is Eagles vs. Giants on today?TV channel (national): FoxTV channel (Philadelphia): WXTF-TVTV channel (New York): WNYWLive stream: fuboTV (7-day free trial)The Eagles vs. Giants game will be shown on Fox to a majority of viewers across the country. For local viewers in Philadelphia and New York, you can find the game broadcast on your Fox affiliate station. Thom Brennaman will call the Eagles vs. Giants play-by-play action, and Chris Spielman will provide analysis.You can also live stream Eagles vs. Giants by signing up for fuboTV, which offers a seven-day free trial.MORE: NFL TV coverage map for Week 17Eagles vs. Giants: What time is kickoff?Date: Sunday, Dec. 29Time: 4:25 p.m. ETThe Eagles vs. Giants game starts at 4:25 p.m. ET on Sunday, Dec. 29. last_img read more